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Behavioural and Psychiatric Symptoms in Patients With Neurodegenerative Diseases

Published online by Cambridge University Press:  21 February 2012

Claire Lomax ,
Richard G. Brown ,
K. Ray Chaudhuri  and
Robert J. Howard
Claire Lomax
Affiliation:
MRC Centre for Neurodegeneration Research, King' College London, Institute of Psychiatry, Department of Psychology.
Richard G. Brown*
Affiliation:
MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, Department of Psychology.
K. Ray Chaudhuri
Affiliation:
Department of Neurology, King's College Hospital.
Robert J. Howard
Affiliation:
MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, Division of Psychological Medicine, Section of Old Age Psychiatry.
*
Address for correspondence: Dr Richard Brown, Department of Psychology, Institute of Psychiatry, PO77, De Crespigny Park, London SE5 8AF, UK. E-mail: r.brown@iop.kcl.ac.uk
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Abstract

Neuropsychiatric symptoms are common features in patients with neurodegenerative diseases, and have important clinical implications for both patients and caregivers. This study used the Neuropsychiatric Inventory (NPI) to measure symptomatology in 120 patients drawn from five disease groups: Parkinson's disease (PD), Alzheimer's disease (AD), dementia associated with Lewy bodies (DLB), multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). Ninety per cent of the patient group reported experiencing at least one symptom, with the most prevalent symptoms being depression and apathy. However, a differential pattern of symptomatology was reported across the disease groups, a finding which has diagnostic and treatment implications. Furthermore, this provides additional evidence that a broad cortical–subcortical distinction cannot be supported.

Type
Articles
Information
Brain Impairment , Volume 6 , Issue 3 , 01 December 2005 , pp. 181 - 190
Copyright
Copyright © Cambridge University Press 2005

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