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Predicting Behavioral Deficits in Pediatric Traumatic Brain Injury Through Uncinate Fasciculus Integrity

Published online by Cambridge University Press:  15 April 2011

Chad P. Johnson ,
Jenifer Juranek ,
Larry A. Kramer ,
Mary R. Prasad ,
Paul R. Swank  and
Linda Ewing-Cobbs
Chad P. Johnson
Affiliation:
Department of Psychology, University of Houston, Houston, Texas
Jenifer Juranek
Affiliation:
Department of Pediatrics, University of Texas Health Science Center at Houston, Houston, Texas
Larry A. Kramer
Affiliation:
Department of Radiology, University of Texas Health Science Center at Houston, Houston, Texas
Mary R. Prasad
Affiliation:
Department of Pediatrics, University of Texas Health Science Center at Houston, Houston, Texas
Paul R. Swank
Affiliation:
Department of Pediatrics, University of Texas Health Science Center at Houston, Houston, Texas
Linda Ewing-Cobbs*
Affiliation:
Department of Pediatrics, University of Texas Health Science Center at Houston, Houston, Texas Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, Texas
*
Correspondence and reprint requests to: Linda Ewing-Cobbs, Dan L Duncan Children's Neurodevelopmental Clinic, Children's Learning Institute, 7000 Fannin, Suite 2401, Houston, TX 77030. E-mail: linda.ewing-cobbs@uth.tmc.edu
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Abstract

Behavioral dysregulation is a common and detrimental consequence of traumatic brain injury (TBI) in children that contributes to poor academic achievement and deficits in social development. Unfortunately, behavioral dysregulation is difficult to predict from either injury severity or early neuropsychological evaluation. The uncinate fasciculus (UF) connects orbitofrontal and anterior temporal lobes, which are commonly implicated in emotional and behavioral regulation. Using probabilistic diffusion tensor tractography (DTT), we examined the relationship between the integrity of the UF 3 months post-injury and ratings of executive functions 12 months post-injury in children with moderate to severe TBI and a comparison group with orthopedic injuries. As expected, fractional anisotropy of the UF was lower in the TBI group relative to the orthopedic injury group. DTT metrics from the UF served as a biomarker and predicted ratings of emotional and behavior regulation, but not metacognition. In contrast, the Glasgow Coma Scale score was not related to either UF integrity or to executive function outcomes. Neuroanatomical biomarkers like the uncinate fasciculus may allow for early identification of behavioral problems and allow for investigation into the relationship of frontotemporal networks to brain-behavior relationships. (JINS, 2011, 17, 663–673)

Keywords

Diffusion tensor imagingExecutive functionNeuropsychologyChildAnisotropyBehavior
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 17 , Issue 4 , 21 June 2011 , pp. 663 - 673
Copyright
Copyright © The International Neuropsychological Society 2011

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