Hostname: page-component-8448b6f56d-cfpbc Total loading time: 0 Render date: 2024-04-20T02:30:36.772Z Has data issue: false hasContentIssue false
  • English
  • Français

The mystery of nuchal translucency

Published online by Cambridge University Press:  03 February 2006

Lindsey D. Allan
Lindsey D. Allan
Affiliation:
Harris Birthright Unit, King's College Hospital, London, United Kingdom
Get access Rights & Permissions [Opens in a new window]

Abstract

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'

Keywords

Fetal cardiologychromosomal malformationsfetal echocardiographycongenital cardiac malformations
Type
The Mannheimer Lecture 2005
Information
Cardiology in the Young , Volume 16 , Issue 1 , January 2006 , pp. 11 - 17
Copyright
© 2006 Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Benacerraf B, Gelman R, Frigoletto FD. Sonographic identification of second-trimester fetuses with Down's syndrome. N Engl J Med 1987; 317: 1371–1374.Google Scholar
Nicolaides KH, Azar G, Byrne D, Mansur C, Marks K. Fetal nuchal translucency: ultrasound screening for chromosomal defects in first trimester of pregnancy. B Med J 1992; 304: 867–869.Google Scholar
Pandya PP, Snijders RJ, Johnson SP, De Lourdes Brizot M, Nicolaides KH. Screening for fetal trisomies by maternal age and fetal nuchal translucency thickness at 10 to 14 weeks of gestation Br J Obstet Gynaecol 1995; 102: 957–962.Google Scholar
Souka AP, Von Kaisenberg CS, Hyett JA, Sonek JD, Nicolaides KH. Increased nuchal translucency with normal karyotype. Am J Obstet Gynecol 2005; 192: 1005–1021.Google Scholar
Anderson DH. Incidence of congenital diaphragmatic hernia in the young of rats bred on a diet deficient in vitamin. Am J Dis Child 1941; 2: 888–889.Google Scholar
Wilson JG, Warkany J. Congenital anomalies of heart and great vessels in offspring of vitamin A-deficient rats. Am J Dis Child 1950; 79: 963–966.Google Scholar
Costlow RD, Manson JM. The heart and diaphragm: target organs in the neonatal death induced by nitrofen (2,4-dichlorophenyl-p-nitrophenyl ether). Toxicology 1981; 20: 209–227.Google Scholar
Migliazza L, Otten C, Xia H, Rodriguez JI, Diez-Pardo JA, Tovar JA. Cardiovascular malformations in congenital diaphragmatic hernia: human and experimental studies. J Pediatr Surg 1999; 34: 1624–1628.Google Scholar
Tasaka H, Takenaka H, Okamoto N, Onisuka T, Koga Y, Hamada M. Abnormal development of cardiovascular systems in rat embryos treated with bisdiamine. Teratology 1991; 43: 191–200.Google Scholar
Mey J, Babiuk RP, Clugston R, Zhang W, Greer JJ. Retinal Dehydrogenase-2 is inhibited by compounds that induce congenital diaphragmatic hernia in rodents. Am J Pathol 2003; 162: 673–679.Google Scholar
Major D, Cadenas M, Fournier L, Leclerc S, Lefebvre M, Cloutier R. Retinol status of newborn infants with congenital diaphragmatic hernia. Pediatr Surg Int 1998; 13: 547–549.Google Scholar
Hyett J, Perdu M, Sharland G, Snijders R, Nicolaides KH. Using fetal nuchal translucency to screen for major congenital cardiac defects at 10–14 weeks of gestation: population based cohort study. BMJ 1999; 318: 81–85.Google Scholar
Mavrides E, Cobian-Sanchez F, Tekay A, et al. Limitations of using first-trimester nuchal translucency measurement. Ultrasound Obstet Gynecol 2001; 17: 106–110.Google Scholar
Michailidis GD, Economides DL. Nuchal translucency measurement and pregnancy outcome in karyotypically normal fetuses. Ultrasound Obstet Gynecol 2001; 17: 102–105.Google Scholar
Makrydimas G, Sotiriadis A, Huggon IC, et al. Nuchal translucency and fetal cardiac defects: a pooled analysis of major fetal echocardiography centres. Am J Obstet Gynecol 2005; 192: 89–95.Google Scholar
Atzei A, Gajewska K, Huggon IC, Allan L, Nicolaides KH. Relationship between nuchal translucency thickness and prevalence of major cardiac defects in fetuses with normal karyotype. Ultrasound Obstet Gynecol 2005; 26: 154–157.Google Scholar
Fiaola S, Tsoi E, Huggon IC, Allan LD, Nicolaides KH. Likelihood ratio for trisomy 21 in fetuses with tricuspid regurgitation at the 11 to 13 + 6-week scan. Ultrasound Obstet Gynecol 2005; 26: 22–27.Google Scholar
Makikallio K, Jouppila P, Rasanen J. Human fetal cardiac function during the first trimester of pregnancy. Heart 2005; 91: 334–338.Google Scholar
Lamers WH, Viragh S, Wessels A, Moorman AFM, Anderson RH. Formation of the tricuspid valve in the human heart. Circulation 1995; 91: 111–121.Google Scholar
Hyett JA, Brizot ML, Von Kaisenberg CS, McKie AT, Farzaneh F, Nicolaides KH. Cardiac gene expression of atrial natriuretic peptide and brain natriuretic peptide in trisomic fetuses. Obstet Gynecol 1996; 87: 506–510.Google Scholar
Huggon IC, Turan O, Allan LD. Doppler assessment of cardiac function at 11–14 weeks' gestation in fetuses with normal and increased nuchal translucency. Ultrasound Obstet Gynecol 2004; 24: 390–398.Google Scholar
Bekker MN, Haak MC, Rekoert-Hollander M, Twisk J, Van Vugt JM. Increased nuchal translucency and distended jugular lymphatic sacs in first-trimester ultrasound. Ultrasound Obstet Gynecol 2005; 25: 239–245.Google Scholar
Stekelenburg-de Vos S, Ursem NT, Hop WC, Wladimiroff JW, Gittenberger-de Groot AC, Poelmann RE. Acutely altered hemodynamics following venous obstruction in the early chick embryo. J Experimental Biol 2003; 206: 1051–1057.Google Scholar
Harh JY, Paul MH, Gallen WJ, Friedberg DZ, Kaplan S. Experimental production of hypoplastic left heart syndrome in the chick embryo. Am J Cardiol 1973; 31: 51–56.Google Scholar
Sedmera D, Cook AC, Shirali G, McQuinn TC. Current issues and perspectives in hypoplasia of the left heart. Cardiol Young 2005; 15: 56–72.Google Scholar
Matias A, Gomes C, Flack N, Montenegro N, Nicolaides KH. Screening for chromosomal abnormalities at 10–14 weeks: the role of ductus venosus blood flow. Ultrasound Obstet Gynecol 1998; 12: 380–384.Google Scholar
Matias A, Huggon I, Areias JC, Montenegro N, Nicolaides KH. Cardiac defects in chromosomally normal fetuses with abnormal ductus venosus blood flow at 10–14 weeks. Ultrasound Obstet Gynecol 1999; 14: 307–310.Google Scholar
Martinez JM, Echevarria M, Gomez O, et al. Jugular vein and carotid artery blood flow in fetuses with increased nuchal translucency at 10–14 weeks gestation. Ultrasound Obstet Gynecol 2003; 22: 464–469.Google Scholar
Sharland GK, Chan KY, Allan LD. Coarctation of the aorta: difficulties in prenatal diagnosis. Br Heart J 1994; 71: 70–75.Google Scholar