Hostname: page-component-8448b6f56d-c4f8m Total loading time: 0 Render date: 2024-04-18T15:16:16.076Z Has data issue: false hasContentIssue false
  • English
  • Français

Bupropion in the treatment of depression in Parkinson's disease

Published online by Cambridge University Press:  01 September 2010

Maria Załuska  and
Agnieszka Dyduch
Maria Załuska
Affiliation:
IV Department of Psychiatry, Institute of Psychiatry and Neurology, Warsaw, Poland
Agnieszka Dyduch*
Affiliation:
Department of Psychiatry, Bielański Hospital, Warsaw, Poland
*
Correspondence should be addressed to: Agnieszka Dyduch, Oddział Psychiatrii, Szpital Bielański, Cegłowska 80, 01-809 Warsaw, Poland. Phone: +48 601 178 946; Fax. +48 22 864 47 46. Email: agabudzisz@wp.pl.
Get access Rights & Permissions [Opens in a new window]

Abstract

A 78-year-old female with a nine-year history of depression was hospitalized due to worsening depression and symptoms associated with Parkinson's disease (PD). Her motor abilities improved on levodopa and the depression improved after a trial of bupropion, following unsuccessful treatment with other antidepressants. We found four reports on successful treatment of depression in PD with bupropion. However, no controlled double-blind studies have been conducted so clinicians should be cautious when administering bupropion in depression in PD.

Keywords

extrapyramidal syndromedepressive symptomspharmacotherapy
Type
Case Report
Information
International Psychogeriatrics , Volume 23 , Issue 2 , March 2011 , pp. 325 - 327
Copyright
Copyright © International Psychogeriatric Association 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bailey, J. and Waters, S. (2008). Acute psychosis after bupropion treatment in a healthy 28-year-old woman. Journal of the American Board of Family Medicine, 21, 244–245. doi: 10.3122/jabfm.2008.03.070236.CrossRefGoogle Scholar
Brommelhoff, J. A., Gatz, M., Johansson, B., McArdle, J. J., Fratiglioni, L. and Pedersen, N. L. (2009). Depression as a risk factor or prodromal feature for dementia? Findings in a population-based sample of Swedish twins. Psychology and Aging, 24, 373–384. doi: 10.1037/a0015713.CrossRefGoogle ScholarPubMed
Gebhardt, S., Röttgers, H., Bäcker, A., Schu, U. and Krieg, J. C. (2008). Treatment of panic disorder with bupropion in a patient with Parkinson's disease. Journal of Clinical Pharmacy and Therapeutics, 33, 575–577. doi: 10.1111/j.1365-2710.2008.00952.x.CrossRefGoogle Scholar
Ghazi-Noori, S., Chung, T. H., Deane, K., Rickards, H. E. and Clarke, C. E. (2009). Therapies for depression in Parkinson's disease. Cochrane Database of Systematic Reviews, 4, 1–19. doi: 10.1002/14651858.CD003465.Google Scholar
Goetz, C. G., Tanner, C. M. and Klawans, H. L. (1984). Bupropion in Parkinson's disease. Neurology, 34, 1092–1094.CrossRefGoogle ScholarPubMed
Grandas, F. and López-Manzanares, L. (2007). Bupropion-induced parkinsonism. Movement Disorders, 22, 1830–1831. doi: 10.1002/mds.21425.CrossRefGoogle ScholarPubMed
Karasu, T. B., Gelenberg, A., Merriam, A. and Wang, P. (2000). Practice Guideline for the Treatment of Patients with Major Depressive Disorder, 2nd edn. Washington, DC: American Psychiatric Association. doi: 10.1176/appi.books.9780890423363.48690.Google Scholar
Leentjens, A. F., Verhey, F. R. and Vreeling, F. W. (2000). Een depressieve patiënte met de ziekte van Parkinson succesvol behandeld met bupropion. [Successful treatment of depression in a Parkinson disease patient with bupropion.] Nederlands Tijdschrift voor Geneeskunde, 144, 2157–2159.Google ScholarPubMed
Remy, P., Doder, M., Lees, A., Turjanski, N. and Brooks, D. (2005). Depression in Parkinson's disease: loss of dopamine and noradrenaline innervation in the limbic system. Brain, 128, 1314–1322. doi: 10.1093/brain/awh445.CrossRefGoogle ScholarPubMed
Shiba, M. et al. (2000). Anxiety disorders and depressive disorders preceding Parkinson's disease: a case-control study. Movement Disorders, 15, 669–677.3.0.CO;2-5>CrossRefGoogle ScholarPubMed
Stein, W. M. and Read, S. (1997). Chronic pain in the setting of Parkinson's disease and depression. Journal of Pain and Symptom Management, 14, 255–258. doi: 10.1016/S0885-3924(97)00176-0.CrossRefGoogle Scholar
Veazey, C., Aki, S. O., Cook, K. F., Lai, E. C. and Kunik, M. E. (2005). Prevalence and treatment of depression in Parkinson's disease. Journal of Neuropsychiatry and Clinical Neurosciences, 17, 310–323. doi: 10.1176/appi.neuropsych.17.3.310.CrossRefGoogle ScholarPubMed