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Impulsivity, dual diagnosis, and the structure of motivated behavior in addiction

Published online by Cambridge University Press:  29 July 2008

R. Andrew Chambers
Affiliation:
Department of Psychiatry, Indiana University School of Medicine, Institute of Psychiatric Research, Indianapolis, IN 46202. robchamb@iupui.edu

Abstract

Defining brain mechanisms that control and adapt motivated behavior will not only advance addiction treatment. It will help society see that addiction is a disease that erodes free will, rather than representing a free will that asks for or deserves consequences of drug-use choices. This science has important implications for understanding addiction's comorbidity in mental illness and reducing associated public health and criminal justice burdens.

Type
Open Peer Commentary
Copyright
Copyright © Cambridge University Press 2008

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References

Bardo, M. T., Donohew, R. L. & Harrington, N. G. (1996) Psychobiology of novelty seeking and drug seeking behavior. Behavioral Brain Research 77(1–2):2343.CrossRefGoogle ScholarPubMed
Belin, D. & Everitt, B. J. (2008) Cocaine-seeking habits depend upon dopamine-dependent serial connectivity linking the ventral and dorsal striatum. Neuron 57:432–41.CrossRefGoogle ScholarPubMed
Chambers, R. A. (2007) Animal modeling and neurocircuitry of dual diagnosis. Journal of Dual Diagnosis 3(2):1929.CrossRefGoogle ScholarPubMed
Chambers, R. A., Bickel, W. K. & Potenza, M. N. (2007) A scale-free systems theory of motivation and addiction. Neuroscience and Biobehavioral Reviews 31(7):1017–45.CrossRefGoogle ScholarPubMed
Chambers, R. A., Jones, R. M., Brown, S. & Taylor, J. R. (2005) Natural reward related learning in rats with neonatal ventral hippocampal lesions and prior cocaine exposure. Psychopharmacology 179(2):470–78.CrossRefGoogle ScholarPubMed
Chambers, R. A. & Potenza, M. N. (2003) Neurodevelopment, impulsivity, and adolescent gambling. Journal of Gambling Studies 19(1):5384.CrossRefGoogle ScholarPubMed
Chambers, R. A. & Self, D. W. (2002) Motivational responses to natural and drug rewards in rats with neonatal ventral hippocampal lesions: An animal model of dual diagnosis schizophrenia. Neuropsychopharmacology 27(6):889905.CrossRefGoogle ScholarPubMed
Chambers, R. A., Taylor, J. R. & Potenza, M. N. (2003) Developmental neurocircuitry of motivation in adolescence: A critical period of addiction vulnerability. American Journal of Psychiatry 160(6):1041–52.CrossRefGoogle ScholarPubMed
Charney, D. S., Nestler, E. J. & Bunney, B. S., eds. (1999) Neurobiology of mental illness. Oxford University Press.Google Scholar
Dixon, L. (1999) Dual diagnosis of substance abuse in schizophrenia: Prevalence and impact on outcomes. Schizophrenia Research 35 (Suppl.):S93100.CrossRefGoogle ScholarPubMed
Everitt, B. J. & Robbins, T. W. (2005) Neural systems of reinforcement for drug addiction: From actions to habits to compulsion. Nature Neuroscience 8(11):1481–89.CrossRefGoogle ScholarPubMed
Finlay, J. M. & Zigmond, M. J. (1997) The effects of stress on central dopaminergic neurons: Possible clinical implications. Neurochemical Research 22(11):1387–94.CrossRefGoogle ScholarPubMed
Gerdeman, G. L., Partridge, J. G., Lupica, C. R. & Lovinger, D. M. (2003) It could be habit forming: Drugs of abuse and striatal synaptic plasticity. Trends in Neuroscience 26(4):184–92.CrossRefGoogle ScholarPubMed
Goto, Y. & Grace, A. A. (2005a) Dopamine-dependent interactions between limbic and prefrontal cortical plasticity in the nucleus accumbens: Disruption by cocaine sensitization. Neuron 47(2):255–66.CrossRefGoogle ScholarPubMed
Goto, Y. & O'Donnell, P. (2002) Delayed mesolimbic system alteration in a developmental animal model of schizophrenia. Journal of Neuroscience 22(20):9070–77.CrossRefGoogle Scholar
Graybiel, A. M. (1998) The basal ganglia and chunking of action repertoires. Neurobiology of Learning and Memory 70(1–2):119–36.CrossRefGoogle ScholarPubMed
Groenewegen, H. J., Wright, C. I., Beijer, A. V. & Voorn, P. (1999) Convergence and segregation of ventral striatal inputs and outputs. Annals of the New York Academy of Sciences 877:4963.CrossRefGoogle ScholarPubMed
Haber, S. N. (2003) The primate basal ganglia: Parallel and integrative networks. Journal of Chemical Neuroanatomy 26:317–30.CrossRefGoogle ScholarPubMed
Haber, S. N., Fudge, J. L. & McFarland, N. R. (2000) Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatum. Journal of Neuroscience 20(6):2369–82.CrossRefGoogle ScholarPubMed
Hyman, S. E. & Malenka, R. C. (2001) Addiction and the brain: The neurobiology of compulsion and its persistence. Nature Reviews Neuroscience 2:695703.CrossRefGoogle ScholarPubMed
Kelley, A. E. (2004b) Ventral striatal control of appetitive motivation: Role in ingestive behavior and reward related learning. Neuroscience and Biobehavioral Reviews 27:765–76.CrossRefGoogle ScholarPubMed
Kessler, R. C. (2004) The epidemiology of dual diagnosis. Biological Psychiatry 56:730–37.CrossRefGoogle ScholarPubMed
Lasser, K., Boyd, J. W., Woolhandler, S., Heimmerlstein, D., McCormick, D. & Bor, D. (2000) Smoking in mental illness: A population-based prevalence study. Journal of the American Medical Association 284(20):2606–10.CrossRefGoogle ScholarPubMed
Lipska, B. K., Lerman, D. N., Khaing, Z. Z. & Weinberger, D. R. (2003) The neonatal ventral hippocampal lesion model of schizophrenia: Effects on dopamine and GABA mRNA markers in the rat midbrain. European Journal of Neuroscience 18:30973104.CrossRefGoogle ScholarPubMed
O'Donnell, P., Greene, J., Pabello, N., Lewis, B. L. & Grace, A. A. (1999) Modulation of cell firing in the nucleus accumbens. Annals of the New York Academy of Sciences 877:157–75.CrossRefGoogle ScholarPubMed
RachBeisel, J., Scott, J. & Dixon, L. (1999) Co-occurring severe mental illness and substance use disorders: A review of recent research. Psychiatric Services 50(11):1427–34.CrossRefGoogle ScholarPubMed
Rosen, M. I., Rosenheck, R. A., Shaner, A., Eckman, T., Gamache, G. & Krebs, C. (2002) Veterans who may need a payee to prevent misuse of funds for drugs. Psychiatric Services 53(8):9951000.CrossRefGoogle Scholar
Schmetzer, A. D. (2006) Deinstitutionalization and dual diagnosis. Journal of Dual Diagnosis 3:95101.CrossRefGoogle Scholar
Spanagel, R. & Weiss, F. (1999) The dopamine hypothesis of reward: Past and current status. Trends in Neurosciences 22(11):521–27.CrossRefGoogle ScholarPubMed
Swanson, L. W. (2000) Cerebral hemisphere regulation of motivated behavior. Brain Research 886(1–2):113–64.CrossRefGoogle ScholarPubMed
Tseng, K. Y., Lewis, B. L., Lipska, B. K. & O'Donnell, P. (2007) Post-pubertal disruption of medial prefrontal cortical dopamine-glutamate interactions in a developmental animal model of schizophrenia. Biological Psychiatry 62:730–38.CrossRefGoogle Scholar
Vanderschuren, L. J. M. J. & Kalivas, P. (2000) Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: A critical review of preclinical studies. Psychopharmacology 151:99120.CrossRefGoogle ScholarPubMed
Volkow, N. D., Wang, G. J., Telang, F., Fowler, J. S., Logan, J., Childress, A. R., Jayne, M., Ma, Y. & Wong, C. (2006) Cocaine cues and dopamine in dorsal striatum: Mechanism of craving in cocaine addiction. Journal of Neuroscience 26:6583–88.CrossRefGoogle ScholarPubMed
Yin, H. H. & Knowlton, B. J. (2006) The role of the basal ganglia in habit formation. Nature Reviews Neuroscience 7:464–76.CrossRefGoogle ScholarPubMed