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Reconciling the mutation-selection balance model with the schizotypy-creativity connection

Published online by Cambridge University Press:  09 November 2006

Daniel Nettle*
Affiliation:
Evolution and Behaviour Research Group, Division of Psychology, University of Newcastle, NewcastleNE2 4HH, United Kingdomhttp://www.staff.ncl.ac.uk/daniel.nettle/

Abstract:

Keller & Miller (K&M) make a persuasive case for the role of mutation-selection balance in the persistence of such disorders as schizophrenia. However, there is evidence relating illness liability to creativity, which seems to imply balancing selection. I argue for a hybrid position, where schizotypal personality traits can have fitness advantages or disadvantages, with mutational load and neurodevelopmental conditions determining which outcome is observed.

Type
Open Peer Commentary
Copyright
Copyright © Cambridge University Press 2006

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