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Disentangling the causal inter-relationship between negative life events and depressive symptoms in women: a longitudinal twin study

Published online by Cambridge University Press:  25 January 2012

M. Wichers ,
H. H. Maes ,
N. Jacobs ,
C. Derom ,
E. Thiery  and
K. S. Kendler
M. Wichers*
Affiliation:
Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
H. H. Maes
Affiliation:
Virginia Commonwealth University, Department of Psychiatry and Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, VA, USA Virginia Commonwealth University, Massey Cancer Center, Richmond, VA, USA
N. Jacobs
Affiliation:
Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands Faculty of Psychology, Open University of the Netherlands, Heerlen, The Netherlands
C. Derom
Affiliation:
Department of Human Genetics, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Belgium
E. Thiery
Affiliation:
Association for Scientific Research in Multiple Births, Ghent, Belgium
K. S. Kendler
Affiliation:
Virginia Commonwealth University, Department of Psychiatry and Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, VA, USA
*
*Address for correspondence: Dr M. Wichers, Department of Psychiatry and Psychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Vijverdalseweg 1, Concorde building, Maastricht, The Netherlands. (Email: m.wichers@sp.unimaas.nl)
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Abstract

Background

Negative life events are strongly associated with the development of depression. However, the etiologic relationship between life events and depression is complex. Evidence suggests that life events can cause depression, and depression increases the risk for life events. Additionally, third factors influencing both phenotypes may be involved. In this work we sought to disentangle these relationships using a genetically informative longitudinal design.

Method

Adult female twins (n=536, including 281 twin pairs) were followed up for measurements of negative life event exposure and depressive symptoms. Four follow-ups were completed, each approximately 3 months apart. Model fitting was carried out using the Mx program.

Results

The best-fitting model included causal paths from life events to depressive symptoms for genetic and shared environmental risk factors, whereas paths from depressive symptoms to life events were apparent for shared environmental factors. Shared latent influence on both phenotypes was found for individual-specific effects.

Conclusions

Life events and depressive symptoms have complex inter-relationships that differ across sources of variance. The results of the model, if replicated, indicate that reducing life event exposure would reduce depressive symptoms and that lowering depressive symptoms would decrease the occurrence of negative life events.

Keywords

Depressive symptomslongitudinal studiesstatistical modellingstressful eventstwins
Type
Original Articles
Information
Psychological Medicine , Volume 42 , Issue 9 , September 2012 , pp. 1801 - 1814
Copyright
Copyright © Cambridge University Press 2012

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References

Brady, SS, Matthews, KA (2002). The influence of socioeconomic status and ethnicity on adolescents' exposure to stressful life events. Journal of Pediatric Psychology 27, 575–583.CrossRefGoogle ScholarPubMed
Brown, GW, Harris, TO, Hepworth, C (1995). Loss, humiliation and entrapment among women developing depression: a patient and non-patient comparison. Psychological Medicine 25, 7–21.CrossRefGoogle ScholarPubMed
Brown, TA, Rosellini, AJ (2011). The direct and interactive effects of neuroticism and life stress on the severity and longitudinal course of depressive symptoms. Journal of Abnormal Psychology 120, 844–856.CrossRefGoogle ScholarPubMed
Christiansen, L, Frederiksen, H, Schousboe, K, Skytthe, A, von Wurmb-Schwark, N, Christensen, K, Kyvik, K (2003). Age- and sex-differences in the validity of questionnaire-based zygosity in twins. Twin Research 6, 275–278.CrossRefGoogle ScholarPubMed
Cole, DA, Nolen-Hoeksema, S, Girgus, J, Paul, G (2006). Stress exposure and stress generation in child and adolescent depression: a latent trait-state-error approach to longitudinal analyses. Journal of Abnormal Psychology 115, 40–51.CrossRefGoogle ScholarPubMed
Derogatis, LR, Lipman, RS, Covi, L (1973). SCL-90: an outpatient psychiatric rating scale – preliminary report. Psychopharmacology Bulletin 9, 13–28.Google ScholarPubMed
Derom, CA, Vlietinck, RF, Thiery, EW, Leroy, FO, Fryns, JP, Derom, RM (2006). The East Flanders Prospective Twin Survey (EFPTS). Twin Research and Human Genetics 9, 733–738.CrossRefGoogle ScholarPubMed
Eaves, LJ, Long, J, Heath, AC (1986). A theory of developmental change in quantitative phenotypes applied to cognitive development. Behavior Genetics 16, 143–162.CrossRefGoogle ScholarPubMed
Farmer, AE, McGuffin, P (2003). Humiliation, loss and other types of life events and difficulties: a comparison of depressed subjects, healthy controls and their siblings. Psychological Medicine 33, 1169–1175.CrossRefGoogle ScholarPubMed
Ge, X, Lorenz, F, Conger, R, Elder, GH, Simons, RL (1994). Trajectories of stressful life events and depressive symptoms during adolescence. Developmental Psychology 30, 467–483.CrossRefGoogle Scholar
Hammen, C (1991). Generation of stress in the course of unipolar depression. Journal of Abnormal Psychology 100, 555–561.CrossRefGoogle ScholarPubMed
Hammen, C (2005). Stress and depression. Annual Review of Clinical Psychology 1, 293–319.CrossRefGoogle ScholarPubMed
Jacobs, N, Nicolson, NA, Derom, C, Delespaul, P, van Os, J, Myin-Germeys, I (2005). Electronic monitoring of salivary cortisol sampling compliance in daily life. Life Sciences 76, 2431–2443.CrossRefGoogle ScholarPubMed
Jang, KL, Livesley, WJ, Vernon, PA (1996). Heritability of the big five personality dimensions and their facets: a twin study. Journal of Personality 64, 577–591.CrossRefGoogle ScholarPubMed
Kendler, KS, Baker, JH (2007). Genetic influences on measures of the environment: a systematic review. Psychological Medicine 37, 615–626.CrossRefGoogle ScholarPubMed
Kendler, KS, Gardner, CO, Prescott, CA (2003 a). Personality and the experience of environmental adversity. Psychological Medicine 33, 1193–1202.CrossRefGoogle ScholarPubMed
Kendler, KS, Gatz, M, Gardner, CO, Pedersen, NL (2006). A Swedish national twin study of lifetime major depression. American Journal of Psychiatry 163, 109–114.CrossRefGoogle ScholarPubMed
Kendler, KS, Hettema, JM, Butera, F, Gardner, CO, Prescott, CA (2003 b). Life event dimensions of loss, humiliation, entrapment, and danger in the prediction of onsets of major depression and generalized anxiety. Archives of General Psychiatry 60, 789–796.CrossRefGoogle ScholarPubMed
Kendler, KS, Jacobson, K, Myers, JM, Eaves, LJ (2008). A genetically informative developmental study of the relationship between conduct disorder and peer deviance in males. Psychological Medicine 38, 1001–1011.CrossRefGoogle ScholarPubMed
Kendler, KS, Karkowski-Shuman, L (1997). Stressful life events and genetic liability to major depression: genetic control of exposure to the environment? Psychological Medicine 27, 539–547.CrossRefGoogle ScholarPubMed
Kendler, KS, Karkowski, LM, Prescott, CA (1999). Causal relationship between stressful life events and the onset of major depression. American Journal of Psychiatry 156, 837–841.CrossRefGoogle ScholarPubMed
Kendler, KS, Neale, M, Kessler, R, Heath, A, Eaves, L (1993 a). A twin study of recent life events and difficulties. Archives of General Psychiatry 50, 789–796.CrossRefGoogle ScholarPubMed
Kendler, KS, Neale, MC, Kessler, RC, Heath, AC, Eaves, LJ (1993 b). A longitudinal twin study of personality and major depression in women. Archives of General Psychiatry 50, 853–862.CrossRefGoogle ScholarPubMed
Kendler, KS, Thornton, LM, Gardner, CO (2000). Stressful life events and previous episodes in the etiology of major depression in women: an evaluation of the ‘kindling’ hypothesis. American Journal of Psychiatry 157, 1243–1251.CrossRefGoogle ScholarPubMed
Kendler, KS, Thornton, LM, Gardner, CO (2001 a). Genetic risk, number of previous depressive episodes, and stressful life events in predicting onset of major depression. American Journal of Psychiatry 158, 582–556.CrossRefGoogle ScholarPubMed
Kendler, KS, Thornton, LM, Prescott, CA (2001 b). Gender differences in the rates of exposure to stressful life events and sensitivity to their depressogenic effects. American Journal of Psychiatry 158, 587–593.CrossRefGoogle ScholarPubMed
Kennedy, N, Paykel, ES (2004). Residual symptoms at remission from depression: impact on long-term outcome. Journal of Affective Disorders 80, 135–144.CrossRefGoogle ScholarPubMed
Kercher, AJ, Rapee, RM, Schniering, CA (2009). Neuroticism, life events and negative thoughts in the development of depression in adolescent girls. Journal of Abnormal Child Psychology 37, 903–915.CrossRefGoogle ScholarPubMed
Markon, KE, Krueger, RF (2004). An empirical comparison of information-theoretic selection criteria for multivariate behavior genetic models. Behavior Genetics 34, 593–610.CrossRefGoogle ScholarPubMed
Middeldorp, CM, Cath, DC, Beem, AL, Willemsen, G, Boomsma, DI (2008). Life events, anxious depression and personality: a prospective and genetic study. Psychological Medicine 38, 1557–1565.CrossRefGoogle ScholarPubMed
Neale, MC, Boker, SM, Xie, G, Maes, H (2003). Mx: Statistical Modeling. Department of Psychiatry, Virginia Commonwealth University Medical School, Box 980126: Richmond, VA 23298.Google Scholar
Paykel, ES (1997). The Interview for Recent Life Events. Psychological Medicine 27, 301–310.CrossRefGoogle ScholarPubMed
Paykel, ES (2003). Life events and affective disorders. Acta Psychiatrica Scandinavica 108 (Suppl. 418), 61–66.CrossRefGoogle Scholar
Peeters, H, Van Gestel, S, Vlietinck, R, Derom, C, Derom, R (1998). Validation of a telephone zygosity questionnaire in twins of known zygosity. Behavior Genetics 28, 159–163.CrossRefGoogle ScholarPubMed
Pettit, JW, Lewinsohn, PM, Seeley, JR, Roberts, RE, Yaroslavsky, I (2011). Developmental relations between depressive symptoms, minor hassles, and major events from adolescence through age 30 years. Journal of Abnormal Psychology 119, 811–824.CrossRefGoogle Scholar
Plomin, R, DeFries, JC, Loehlin, JC (1977). Genotype-environment interaction and correlation in the analysis of human behavior. Psychological Bulletin 84, 309–322.CrossRefGoogle ScholarPubMed
Raftery, AE (1995). Sociological Methodology. Blackwell: Oxford, UK.Google Scholar
Rijsdijk, FV, Sham, PC, Sterne, A, Purcell, S, McGuffin, P, Farmer, A, Goldberg, D, Mann, A, Cherny, SS, Webster, M, Ball, D, Eley, TC, Plomin, R (2001). Life events and depression in a community sample of siblings. Psychological Medicine 31, 401–410.CrossRefGoogle Scholar
Schwartz, G (1978). Estimating the dimension of a model. Annals of Statistics 6, 461–464.Google Scholar
Silberg, J, Rutter, M, Neale, M, Eaves, L (2001). Genetic moderation of environmental risk for depression and anxiety in adolescent girls. British Journal of Psychiatry 179, 116–121.CrossRefGoogle ScholarPubMed
Spitz, E, Moutier, R, Reed, T, Busnel, MC, Marchaland, C, Roubertoux, PL, Carlier, M (1996). Comparative diagnoses of twin zygosity by SSLP variant analysis, questionnaire, and dermatoglyphic analysis. Behavior Genetics 26, 55–63.CrossRefGoogle ScholarPubMed
Thapar, A, Harold, G, McGuffin, P (1998). Life events and depressive symptoms in childhood: shared genes or shared adversity? A research note. Journal of Child Psychology and Psychiatry 39, 1153–1158.CrossRefGoogle ScholarPubMed
Van Os, J, Jones, PB (1999). Early risk factors and adult person–environment relationships in affective disorder. Psychological Medicine 29, 1055–1067.CrossRefGoogle ScholarPubMed
Viken, RJ, Rose, RJ, Kaprio, J, Koskenvuo, M (1994). A developmental genetic analysis of adult personality: extraversion and neuroticism from 18 to 59 years of age. Journal of Personality and Social Psychology 66, 722–730.CrossRefGoogle ScholarPubMed
Vinkhuyzen, AA, van der Sluis, S, de Geus, EJ, Boomsma, DI, Posthuma, D (2010). Genetic influences on ‘environmental’ factors. Genes, Brain and Behavior 9, 276–287.CrossRefGoogle ScholarPubMed
Wang, JL, Schmitz, N, Dewa, C (2010). Socioeconomic status and the risk of major depression: the Canadian National Population Health Survey. Journal of Epidemiology and Community Health 64, 447–452.CrossRefGoogle ScholarPubMed
Wichers, M, Myin-Germeys, I, Jacobs, N, Peeters, F, Kenis, G, Derom, C, Vlietinck, R, Delespaul, P, van Os, J (2007). Genetic risk of depression and stress-induced negative affect in daily life. British Journal of Psychiatry 191, 218–223.CrossRefGoogle ScholarPubMed
Wichers, M, Schrijvers, D, Geschwind, N, Jacobs, N, Myin-Germeys, I, Thiery, E, Derom, C, Sabbe, B, Peeters, F, Delespaul, P, van Os, J (2009). Mechanisms of gene-environment interactions in depression: evidence that genes potentiate multiple sources of adversity. Psychological Medicine 39, 1077–1086.CrossRefGoogle ScholarPubMed
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