Hostname: page-component-8448b6f56d-cfpbc Total loading time: 0 Render date: 2024-04-24T12:36:55.837Z Has data issue: false hasContentIssue false

Brain volume changes in schizophrenia: how do they arise? what do they mean?

A commentary on ‘Do antipsychotic drugs affect brain structure? A systematic and critical review of MRI findings’ by Navari & Dazzan (2009)

Published online by Cambridge University Press:  20 April 2009

D. A. Lewis*
Affiliation:
Departments of Psychiatry and Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA
*
*Address for correspondence: D. A. Lewis, M.D., Departments of Psychiatry and Neuroscience, University of Pittsburgh, W1652 BST, 3811 O'Hara Street, Pittsburgh, PA15213, USA. (Email: lewisda@upmc.edu)

Abstract

Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Commentary
Copyright
Copyright © Cambridge University Press 2009

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Borgwardt, SJ, McGuire, PK, Aston, J, Gschwandtner, U, Pfluger, MO, Stieglitz, RD, Radue, EW, Riecher-Rossler, A (2008). Reductions in frontal, temporal and parietal volume associated with the onset of psychosis. Schizophrenia Research 106, 108114.CrossRefGoogle ScholarPubMed
Cannon, TD, Cadenhead, K, Cornblatt, B, Woods, SW, Addington, J, Walker, E, Seidman, LJ, Perkins, D, Tsuang, M, McGlashan, T, Heinssen, R (2008). Prediction of psychosis in youth at high clinical risk: a multisite longitudinal study in North America. Archives of General Psychiatry 65, 2837.CrossRefGoogle ScholarPubMed
Dorph-Petersen, K-A, Pierri, JN, Perel, JM, Sun, Z, Sampson, AR, Lewis, DA (2005). The influence of chronic exposure to antipsychotic medications on brain size before and after tissue fixation: a comparison of haloperidol and olanzapine in macaque monkeys. Neuropsychopharmacology 30, 16491661.CrossRefGoogle ScholarPubMed
Konopaske, GT, Dorph-Petersen, KA, Pierri, JN, Wu, Q, Sampson, AR, Lewis, DA (2007). Effect of chronic exposure to antipsychotic medication on cell numbers in the parietal cortex of macaque monkeys. Neuropsychopharmacology 32, 12161223.CrossRefGoogle ScholarPubMed
Konopaske, GT, Dorph-Petersen, K-A, Sweet, RA, Pierri, JN, Zhang, W, Sampson, AR, Lewis, DA (2008). Effect of chronic antipsychotic exposure on astrocyte and oligodendrocyte numbers in macaque monkeys. Biological Psychiatry 63, 759765.CrossRefGoogle ScholarPubMed
Navari, S, Dazzan, P (2009). Do antipsychotic drugs affect brain structure? A systematic and critical review of MRI findings. Psychological Medicine. Published online: 2 April 2009. doi:10.1017/S0033291709005315.CrossRefGoogle ScholarPubMed
Pierri, JN, Chaudry, AS, Woo, T-U, Lewis, DA (1999). Alterations in chandelier neuron axon terminals in the prefrontal cortex of schizophrenic subjects. American Journal of Psychiatry 156, 17091719.CrossRefGoogle ScholarPubMed