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Association of the DTNBP1 genotype with cognition and personality traits in healthy subjects

Published online by Cambridge University Press:  01 April 2009

T. Kircher ,
V. Markov ,
A. Krug ,
T. Eggermann ,
K. Zerres ,
M. M. Nöthen ,
M. H. Skowronek  and
M. Rietschel
T. Kircher*
Affiliation:
Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Germany
V. Markov
Affiliation:
Department of Psychiatry and Psychotherapy, RWTH Aachen University, Germany
A. Krug
Affiliation:
Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Germany
T. Eggermann
Affiliation:
Institute of Human Genetics, RWTH Aachen University, Germany
K. Zerres
Affiliation:
Institute of Human Genetics, RWTH Aachen University, Germany
M. M. Nöthen
Affiliation:
Department of Genomics, Life and Brain Centre, University of Bonn, Germany
M. H. Skowronek
Affiliation:
Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany
M. Rietschel
Affiliation:
Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany
*
*Address for correspondence: Dr T. Kircher, Department of Psychiatry und Psychotherapy, Philipps-University Marburg, Rudolf-Bultmann-Straße 8, D-35039 Marburg, Germany. (Email: psychiat@med.uni-marburg.de)
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Abstract

Background

Schizophrenia is a complex disorder with a high heritability. Family members have an increased risk not only for schizophrenia per se but also for schizophrenia spectrum disorders. Impairment of neuropsychological functions found in schizophrenia patients are also frequently observed in their relatives. The dystrobrevin-binding protein 1 (DTNBP1) gene located at chromosome 6p22.3 is one of the most often replicated vulnerability genes for schizophrenia. In addition, this gene has been shown to modulate general cognitive abilities both in healthy subjects and in patients with schizophrenia.

Method

In a sample of 521 healthy subjects we investigated an association between the DTNBP1 genotype [single nucleotide polymorphism (SNP) rs1018381], personality traits [using the NEO Five-Factor Inventory (NEO-FFI) and the Schizotypal Personality Questionnaire – Brief Version (SPQ-B)] and cognitive function (estimated IQ, verbal fluency, attention, working memory and executive function).

Results

Significantly lower scores on the SPQ-B (p=0.0005) and the Interpersonal Deficit subscale (p=0.0005) in carriers of the A-risk allele were detected. There were no differences in any of the cognitive variables between groups.

Conclusions

The results indicate that genetic variation of the DTNBP1 genotype might exert gene-specific modulating effects on schizophrenia endophenotypes at the population level.

Keywords

DysbindinP1578rs1018381schizophreniaschizotypy
Type
Original Articles
Information
Psychological Medicine , Volume 39 , Issue 10 , October 2009 , pp. 1657 - 1665
Copyright
Copyright © Cambridge University Press 2009

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