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Alzheimer's disease and Down's syndrome: an in vivo MRI study

Published online by Cambridge University Press:  30 July 2008

F. Beacher ,
E. Daly ,
A. Simmons ,
V. Prasher ,
R. Morris ,
C. Robinson ,
S. Lovestone ,
K. Murphy  and
D. G. M. Murphy
F. Beacher
Affiliation:
Institute of Psychiatry, King's College, London, UK Section of Brain Maturation, Department of Psychological Medicine, Institute of Psychiatry, King's College, London, UK
E. Daly
Affiliation:
Institute of Psychiatry, King's College, London, UK Section of Brain Maturation, Department of Psychological Medicine, Institute of Psychiatry, King's College, London, UK
A. Simmons
Affiliation:
Institute of Psychiatry, King's College, London, UK Neuroimaging Research Group, Institute of Psychiatry, King's College, London, UK
V. Prasher
Affiliation:
Greenfields Monyhull Hospital, Kings Norton, Birmingham, UK
R. Morris
Affiliation:
Institute of Psychiatry, King's College, London, UK Department of Psychology, Institute of Psychiatry, King's College, London, UK
C. Robinson
Affiliation:
Greenfields Monyhull Hospital, Kings Norton, Birmingham, UK
S. Lovestone
Affiliation:
Institute of Psychiatry, King's College, London, UK Departments of Old Age Psychiatry and Neuroscience, Institute of Psychiatry, King's College, London, UK
K. Murphy
Affiliation:
Institute of Psychiatry, King's College, London, UK Section of Brain Maturation, Department of Psychological Medicine, Institute of Psychiatry, King's College, London, UK College of Surgeons, Dublin, Ireland
D. G. M. Murphy*
Affiliation:
Institute of Psychiatry, King's College, London, UK Section of Brain Maturation, Department of Psychological Medicine, Institute of Psychiatry, King's College, London, UK
*
*Address for correspondence: Dr D. G. M. Murphy, P50, Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK. (Email: sphadgm@iop.kcl.ac.uk)
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Abstract

Background

Individuals with Down's syndrome (DS) are at high risk of developing Alzheimer's disease (AD). However, few studies have investigated brain anatomy in DS individuals with AD.

Method

We compared whole brain anatomy, as measured by volumetric magnetic resonance imaging (MRI), in DS individuals with and without AD. We also investigated whether volumetric differences could reliably classify DS individuals according to AD status. We used volumetric MRI and manual tracing to examine regional brain anatomy in 19 DS adults with AD and 39 DS adults without AD.

Results

DS individuals with AD had significantly smaller corrected volumes bilaterally of the hippocampus and caudate, and right amygdala and putamen, and a significantly larger corrected volume of left peripheral cerebrospinal fluid (CSF), compared to DS individuals without AD. The volume of the hippocampus and caudate nucleus correctly categorized 92% and 92% respectively of DS individuals without AD, and 75% and 80% respectively of DS individuals with AD.

Conclusions

DS individuals with AD have significant medial temporal and striatal volume reductions, and these may provide markers of clinical AD.

Keywords

Alzheimer's diseasecaudatedementiadiagnosisDown's syndromehippocampusmagnetic resonance imaging
Type
Original Articles
Information
Psychological Medicine , Volume 39 , Issue 4 , April 2009 , pp. 675 - 684
Copyright
Copyright © 2008 Cambridge University Press

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