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A controlled evaluation of lithium prophylaxis in affective disorders

Published online by Cambridge University Press:  09 July 2009

R. L. Cundall
Affiliation:
From the M.R.C. Brain Metabolism Unit3, Royal Edinburgh Hospital, Edinburgh
P. W. Brooks
Affiliation:
From the M.R.C. Brain Metabolism Unit3, Royal Edinburgh Hospital, Edinburgh
L. G. Murray
Affiliation:
From the M.R.C. Brain Metabolism Unit3, Royal Edinburgh Hospital, Edinburgh

Synopsis

In a double-blind crossover trial lithium carbonate was found to be significantly superior to placebo in the prophylaxis of manic-depressive (bipolar) psychosis. A striking feature was the high incidence of manic or hypomanic attacks in patients who relapsed on placebo. Patients participated in the trial with their full knowledge and consent.

Type
Preliminary communication
Copyright
Copyright © Cambridge University Press 1972

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References

REFERENCES

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Coppen, A., Noguera, R., Bailey, J., Burns, B. H., Swani, M. S., Hare, E. H., Gardner, R., and Maggs, R. (1971). Prophylactic lithium in affective disorders. Controlled trial. Lancet, 2, 275279.CrossRefGoogle ScholarPubMed
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