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The role of splenectomy in HIV-infected patients with relapsing visceral leishmaniasis

Published online by Cambridge University Press:  11 December 2006

J. TROYA ,
A. CASQUERO ,
G. MUÑIZ ,
M. L. FERNÁNDEZ-GUERRERO  and
M. GÓRGOLAS
J. TROYA*
Affiliation:
Division of Infectious Diseases, Fundación Jiménez Díaz-UTE, Universidad Autónoma de Madrid, Avda. de Reyes Católicos 2, 28040 Madrid, Spain
A. CASQUERO
Affiliation:
Division of Infectious Diseases, Fundación Jiménez Díaz-UTE, Universidad Autónoma de Madrid, Avda. de Reyes Católicos 2, 28040 Madrid, Spain
G. MUÑIZ
Affiliation:
Servicio de Medicina Interna, Hospital General de Toledo, Av Barber 30, 45004 Toledo, Spain
M. L. FERNÁNDEZ-GUERRERO
Affiliation:
Division of Infectious Diseases, Fundación Jiménez Díaz-UTE, Universidad Autónoma de Madrid, Avda. de Reyes Católicos 2, 28040 Madrid, Spain
M. GÓRGOLAS
Affiliation:
Division of Infectious Diseases, Fundación Jiménez Díaz-UTE, Universidad Autónoma de Madrid, Avda. de Reyes Católicos 2, 28040 Madrid, Spain
*
*Corresponding author: Division of Infectious Diseases, Fundación Jiménez Díaz-UTE, Universidad Autónoma de Madrid, Avda. de Reyes Católicos 2, 28040 Madrid, Spain. Tel: +34656803796. E-mail: jestrogar@hotmail.com
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Summary

The treatment of visceral leishmaniasis (VL) in HIV-infected patients is characterized by having a protracted course and frequent relapses, despite the use of adequate anti-leishmanial drugs and effective anti-retroviral therapy. A small subset of patients with significant splenomegaly develops severe cytopaenias and chronic leishmania infection. The use of elective splenectomy is effective for restoring the haematological parameters and reduces the need for blood transfusions but it does not avoid relapsing visceral leishmaniasis.

Keywords

visceral leishmaniasisHIV-infected patientssplenectomy
Type
Research Article
Information
Parasitology , Volume 134 , Issue 5 , May 2006 , pp. 621 - 624
Copyright
Copyright © Cambridge University Press 2006

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