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Biology of the schistosome lung-stage schistosomulum

Published online by Cambridge University Press:  17 November 2006

G. N. GOBERT
Affiliation:
Molecular Parasitology Laboratory, Infectious Diseases and Immunology Division and Australian Centre for International Health and Nutrition, The Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland 4006 Australia
M. CHAI
Affiliation:
Molecular Parasitology Laboratory, Infectious Diseases and Immunology Division and Australian Centre for International Health and Nutrition, The Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland 4006 Australia
D. P. McMANUS
Affiliation:
Molecular Parasitology Laboratory, Infectious Diseases and Immunology Division and Australian Centre for International Health and Nutrition, The Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland 4006 Australia

Abstract

Past and more recent research has examined the ultrastructure, metabolism, cell biology, genomics and post-genomics of schistosome schistosomula. These areas are considered and discussed in this review with particular emphasis on (1) the early migration phases through the host, (2) interaction of the host immune response with the parasite surface, (3) glucose uptake mechanisms, and (4) defining the transcriptional profiles of lung-stage schistosomula compared with other developmental stages using microarrays. The microarray profiling studies suggest caution is required when considering the use of schistosomes obtained by in vitro means for molecular or biochemical studies.

Type
Review Article
Copyright
© 2006 Cambridge University Press

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