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Measurement of malarial infectivity of human populations to mosquitoes in the Madang area, Papua New Guinea

Published online by Cambridge University Press:  06 April 2009

P. M. Graves
Affiliation:
Papua New Guinea Institute of Medical Research, P.O. Box 378, Madang, Papua New Guinea
T. R. Burkot
Affiliation:
Papua New Guinea Institute of Medical Research, P.O. Box 378, Madang, Papua New Guinea
R. Carter
Affiliation:
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md 20792, USA
J. A. Cattani
Affiliation:
Papua New Guinea Institute of Medical Research, P.O. Box 378, Madang, Papua New Guinea
M. Lagog
Affiliation:
Papua New Guinea Institute of Medical Research, P.O. Box 378, Madang, Papua New Guinea
J. Parker
Affiliation:
Papua New Guinea Institute of Medical Research, P.O. Box 378, Madang, Papua New Guinea
B. J. Brabin
Affiliation:
Papua New Guinea Institute of Medical Research, P.O. Box 378, Madang, Papua New Guinea
F. D. Gibson
Affiliation:
Papua New Guinea Institute of Medical Research, P.O. Box 378, Madang, Papua New Guinea
D. J. Bradley
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel St, LondonWC1E 7HT, England
M. P. Alpers
Affiliation:
Papua New Guinea Institute of Medical Research, P.O. Box 378, Madang, Papua New Guinea

Summary

The proportion of blood meals taken on humans which are infectious to mosquitoes in the Madang area, Papua New Guinea was estimated by two methods. In the first, laboratory reared Anopheles farauti were fed on individuals of all ages at village surveys. The results showed that 3·8% of people were infectious and that the mean percentage of mosquitoes which became infected by feeding on these people was 37·9%. From the average proportion of mosquitoes infected, the probability that a mosquito feeding on a human would pick up infection was 0·013±0·005. In the second approach mosquitoes were fed on identified Plasmodium falciparum, P. vivax and P. malariae gametocyte carriers. The results indicated that 46% of gametocyte carriers were infectious and that the mean probability of a mosquito becoming infected after feeding on a gametocyte carrier was 0·151±0·029. Gametocyte prevalence rates in all ages measured over 18 months in three villages averaged 3·3% P. falciparum, 4·0% P. vivax and 0·7% P. malariae, totalling 8·0±0·7%. Combining gametocyte prevalence rates with the probability of a mosquito becoming infected from a gametocyte carrier, the probability of a mosquito becoming infected following a blood meal on a member of the human population was estimated to be 0·012±0·003.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1988

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References

REFERENCES

Burkot, T. R., Graves, P. M., Cattani, J. A., Wirtz, R. A. & Gibson, F. D. (1987). The efficiency of sporozoite transmission in the human malarias Plasmodium falciparum and P. vivax. Bulletin of the World Health Organization 65, 375–80.Google ScholarPubMed
Cattani, J., Moir, J. S., Gibson, F. D., Ginny, M., Paino, J., Davidson, W. & Alpers, M. P. (1986 a). Small area variations in the epidemiology of malaria in Madang Province. Papua New Guinea Medical Journal 29, 1118.Google ScholarPubMed
Cattani, J. A., Tulloch, J. L., Vrbova, H., Jolley, D., Gibson, F. D., Moir, J. S., Heywood, P. H., Alpers, M. P., Stevenson, A. & Clancy, R. (1986 b). The epidemiology of malaria in a population surrounding Madang, Papua New Guinea. American Journal of Tropical Medicine and Hygiene 35, 315.CrossRefGoogle Scholar
Charlwood, J. D., Graves, P. M. & Birley, M. H. (1986). Capture–recapture studies with mosquitoes of the group of Anopheles punctulatus Donitz (Diptera, Culicidae) from Papua New Guinea. Bulletin of Entomological Research 76, 211–27.CrossRefGoogle Scholar
Graves, P. M., Carter, R., Burkot, T. R., Quakyi, I. A. & Kumar, N. K. (1987). Antibodies to Plasmodium falciparum gamete surface antigens in Papua New Guinea sera. Parasite Immunology (in the Press).Google Scholar
Mendis, K., Munasinghe, Y. D., De Silva, Y. N. Y., Keragalla, I. & Carter, R. (1987). Malaria transmission blocking immunity induced by natural infections of Plasmodium vivax in humans. Infection and Immunity 55, 369–72.CrossRefGoogle ScholarPubMed
Metselaar, D. (1957). A pilot project of residual insecticide spraying in Netherlands New Guinea; contribution to the knowledge of holo-endemic malaria. Acta Leidensia 27, 1128.Google Scholar
Metselaar, D. (1960). Relative increase in the prevalence of Plasmodium falciparum some years after the beginning of a house spraying campaign in Netherlands New Guinea. Transactions of the Royal Society of Tropical Medicine and Hygiene 54, 523–8.CrossRefGoogle ScholarPubMed
Moir, J. S., Tulloch, J. L., Vrbova, H., Jolley, D. J., Heywood, P. F. & Alpers, M. P. (1986). The role of voluntary village aides in the treatment of malaria by presumptive treatment of fever. 2. Impact on village health. Papua New Guinea Medical Journal 28, 267–78.Google Scholar
Molineaux, L. & Gramiccia, G. (1980). The Garki Project. Geneva: World Health Organization.Google Scholar
Muirhead-Thomson, R. C. (1954). Factors determining the true reservoir of infection of Plasmodium falciparum and Wuchereria bancrofti in a West African village. Transactions of the Royal Society of Tropical Medicine and Hygiene 48, 208–25.CrossRefGoogle Scholar
Muirhead-Thomson, R. C. (1957). The malarial infectivity of an African village population to mosquitoes (Anopheles gambiae). A random xenodiagnostic survey. American Journal of Tropical Medicine and Hygiene 6, 971–9.CrossRefGoogle ScholarPubMed
Peters, W. (1957). Report on a malaria survey in the Sepik district. Medical Journal of Australia 44, 861–8.CrossRefGoogle ScholarPubMed