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Vocal fold mobility as the main prognostic factor of treatment outcomes and survival in stage II squamous cell carcinomas of the glottic larynx

Published online by Cambridge University Press:  23 July 2015

P Gorphe*
Affiliation:
Department of Head and Neck Oncology, Institut Gustave Roussy, Villejuif, France
P Blanchard
Affiliation:
Department of Radiotherapy, Institut Gustave Roussy, Villejuif, France
I Breuskin
Affiliation:
Department of Head and Neck Oncology, Institut Gustave Roussy, Villejuif, France
S Temam
Affiliation:
Department of Head and Neck Oncology, Institut Gustave Roussy, Villejuif, France
Y Tao
Affiliation:
Department of Radiotherapy, Institut Gustave Roussy, Villejuif, France
F Janot
Affiliation:
Department of Radiotherapy, Institut Gustave Roussy, Villejuif, France
*
Address for correspondence: Dr P Gorphe, Department of Head and Neck Oncology, Institut Gustave Roussy, 114 rue Edouard Vaillant, F-94800 Villejuif, France E-mail: philippe.gorphe@gustaveroussy.fr

Abstract

Objective:

This study aimed to assess the influence of supra- and subglottic extensions and vocal fold mobility on outcome in a large monocentric cohort of 148 patients treated for tumour–node–metastasis stage T2N0 glottic carcinomas.

Methods:

In all, 107 glottic carcinoma patients had normal vocal fold mobility (T2aN0), and 41 had impaired vocal fold mobility (T2bN0). Treatment decisions were made by a multidisciplinary team.

Results:

Vocal fold mobility was associated with overall survival, disease-free survival, local control, larynx preservation and laryngectomy-free survival. For patients with T2a lesions, local control, laryngectomy-free survival and disease-free survival improved after surgery but overall survival did not. For patients with T2b lesions, local control, laryngectomy-free survival, disease-free survival and overall survival were all higher after surgery than after radiotherapy.

Conclusion:

This study highlights for the first time the importance of vocal fold mobility in treatment outcomes and is the first to assess its influence on survival. Updated tumour–node–metastasis classifications should consider the distinction between T2a and T2b lesions.

Type
Main Articles
Copyright
Copyright © JLO (1984) Limited 2015 

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Footnotes

Presented as an oral presentation at the 5th world congress of the International Federation of Head and Neck Oncologic Societies, 28 July 2014, New York, USA

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