Hostname: page-component-848d4c4894-5nwft Total loading time: 0 Render date: 2024-05-19T17:50:58.077Z Has data issue: false hasContentIssue false

Acrokeratosis paraneoplastica: Bazex syndrome

Published online by Cambridge University Press:  29 June 2007

Michael J. Wareing*
Affiliation:
Department of Otolaryngology: Head and Neck Surgery, Guys' and St. Thomas' Hospitals NHS Trust, London, UK.
Samantha A. Vaughan-Jones
Affiliation:
Department of Otolaryngology: St John's Institute of Dermatology, St Thomas' Hospital, London, UK.
David H. McGibbon
Affiliation:
Department of Otolaryngology: St John's Institute of Dermatology, St Thomas' Hospital, London, UK.
*
Address for correspondence: Mr M. J. Wareing, 14 Woodlands Park Road, Greenwich, SE10 9XD.

Abstract

Bazex syndrome, or acrokeratosis paraneoplastica, is a cutaneous paraneoplastic syndrome characterized by psoriasiform lesions associated with, usually, a squamous cell carcinoma of the upper aerodigestive tract. We present a case of Bazex syndrome associated with metastatic cervical squamous cell carcinoma with an unknown primary. The features of the condition are discussed in the light of current knowledge.

Type
Clinical Records
Copyright
Copyright © JLO (1984) Limited 1996

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bazex, A., Griffiths, A. (1980) Acrokeratosis paraneoplastica - a new cutaneous marker of malignancy. British Journal of Dermatology 102: 301306.CrossRefGoogle Scholar
Bolognia, J. A., Brewer, Y. P., Cooper, D. L. (1991) Bazex syndrome (acrokeratosis paraneoplastica). Medicine 70(4): 269280.CrossRefGoogle ScholarPubMed
Douglas, W. S., Bilsland, D. J., Howatson, R. (1991) Acrokeratosis paraneoplastica of Basex - a case in the UK. Clinical and Experimental Dermatology 16: 297299.CrossRefGoogle Scholar
Halpern, S. M., O'Donnell, L. J. D., Makunura, C. N. (1995) Acrokeratosis paraneoplastica of Bazex in association with a metastatic neuroendocrine tumour. Journal of the Royal Society of Medicine 88: 353354.Google ScholarPubMed
Handfield-Jones, S. E., Matthews, C. N. A., Ellis, J. P., Das, K. B., McGibbon, D. H. (1992) Acrokeratosis paraneoplastica of Basex. Journal of the Royal Society of Medicine 85: 548550.Google Scholar
Hara, M., Hunayama, M., Aiba, S., Suetake, T., Watanabe, M., Tanaka, M., Tagami, H. (1995) Acrokeratosis paraneoplastica (Bazex syndrome) associated with primary cutaneous squamous cell carcinoma of the lower leg, vitiligo and alopecia areata. British Journal of Dermatology 133: 121124.Google Scholar
Lever, W. F., Schaumburg-Lever, G. (1990) In Histopathology of the Skin. 7th Edition, J. B. Lippincott and Co., Philadelphia, pp 103112, 156174, 284285, 494506.Google Scholar
Lucker, G. P. H., Steijlen, P. M. (1995) Acrokeratosis paraneoplastica (Bazex syndrome) occurring with acquired ichthyosis in Hodgkin's disease. British Journal of Dermatology 133: 322325.CrossRefGoogle ScholarPubMed
Martin, R. W., Cornitius, T. G., Naylor, M. F., Neldner, K. H. (1989) Bazex's syndrome in a woman with pulmonary adenocarcinoma. Archives of Dermatology 125: 847848.CrossRefGoogle Scholar
Pecora, A. L., Landsman, L., Imgrund, S. P., Lambert, C. (1983) Acrokeratosis paraneoplastica (Bazex syndrome). Report of a case and review of the literature. Archives of Dermatology 119: 820826.CrossRefGoogle ScholarPubMed
Saito, K., Tamura, A., Narimatsu, H., Tadakuma, T., Nagashima, N. (1986) Cloned auto-la-reactive T cells elicit lichen planus-like lesion in the skin of syngeneic mice. Journal of Immunology 137: 24852495.Google Scholar
Wishart, J. M. (1986) Bazex paraneoplastic acrokeratosis: a case report and response to Tigason. British Journal of Dermatology 115: 595599.Google Scholar