Hostname: page-component-8448b6f56d-qsmjn Total loading time: 0 Render date: 2024-04-23T09:50:27.887Z Has data issue: false hasContentIssue false
  • English
  • Français

The faecal flora of patients with Crohn's disease

Published online by Cambridge University Press:  25 March 2010

F. Wensinck ,
L. M. C. Custers-van Lieshout ,
P. A. J. Poppelaars-Kustermans  and
A. M. Schröder
F. Wensinck
Affiliation:
Department of Medical Microbiology, Erasmus University, Rotterdam, The Netherlands
L. M. C. Custers-van Lieshout
Affiliation:
Department of Medical Microbiology, Erasmus University, Rotterdam, The Netherlands
P. A. J. Poppelaars-Kustermans
Affiliation:
Department of Medical Microbiology, Erasmus University, Rotterdam, The Netherlands
A. M. Schröder
Affiliation:
Department of Medical Microbiology, Erasmus University, Rotterdam, The Netherlands
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The faecal flora of patients with Crohn's disease was compared with that of healthy subjects. In patients with terminal ileitis, numbers of anaerobic gramnegative and coccoid rods (species of Eubacterium and Peptostreptococcus) were higher than in the controls whereas anaerobic gram-positive rods and cocci and aerobes occurred in normal numbers. The composition of the flora was neither influenced by duration of the disease nor by ileocaecal resection. In healthy subjects and patients, a chemically defined diet induced only slight changes in the flora. Thus, the flora in terminal ileitis although stable was permanently abnormal.

In patients with Crohn's colitis, abnormally low numbers of anaerobes were found in patients with severe, bloody diarrhoea while aerobic counts were normal. The flora in patients with mild colitis was similar to that in terminal ileitis. It is suggested that the abnormal flora composition might be an expression of the genetic predisposition to Crohn's disease.

Type
Research Article
Information
Journal of Hygiene , Volume 87 , Issue 1 , August 1981 , pp. 1 - 12
Copyright
Copyright © Cambridge University Press 1981

References

Aries, V. C., Crowther, J. S., Drasar, B. S., Hill, M. J. & Ellis, F. R. (1971). The effect of a strict vegetarian diet on the faecal flora and faecal steroid concentration. Journal of Pathology 103, 54.CrossRefGoogle ScholarPubMed
Attebery, H. R., Suter, V. L. & Finegold, S. M. (1972). Effect of a partially chemically defined diet on normal human fecal flora. American Journal of Clinical Nutrition 25, 1391.CrossRefGoogle ScholarPubMed
Axelsson, C. K. & Justesen, T. (1977). Studies of the duodenal and fecal flora in gastrointestinal disorders during treatment with an elemental diet. Gastroenterology 72, 397.CrossRefGoogle ScholarPubMed
Bornside, G. H. & Cohn, I. (1975). Stability of normal human fecal flora during a chemically defined, low residue liquid diet. Annals of Surgery 181, 58.CrossRefGoogle ScholarPubMed
Bounous, G. & Devroede, G. J. (1974). Effects of an elemental diet on human fecal flora. Gastroenterology 66, 210.CrossRefGoogle ScholarPubMed
Crowther, J. S., Drasar, B. S., Goddard, P., Hill, M. J. & Johnson, K.. (1973). The effect of a chemically defined diet on the faecal flora and faecal steroid concentration. Gut 14, 790.CrossRefGoogle ScholarPubMed
Drasar, B. S., Jenkins, D. J. A. & Cummings, J. H. (1976). The influence of a diet rich in wheat fibre on the human faecal flora. Journal of Medical Microbiology 9, 423.CrossRefGoogle Scholar
Finegold, S. M., Attebery, H. R. & Suter, V. L. (1974). Effect of diet on human fecal flora: comparison of Japanese and American diets. American Journal of Clinical Nutrition 27, 1456.CrossRefGoogle ScholarPubMed
Gorbach, S. L., Banwell, J. G., Chatterjee, B. D., Jacobs, B. & Sack, R. B. (1971). Acute undifferentiated human diarrhoea in the tropics. Journal of Clinical Investigation 50, 881.CrossRefGoogle ScholarPubMed
Gorbach, S. L., Banwell, J. G., Jacobs, B., Chatterjee, B. D., Mitra, R., Brigham, K. L. & Neogy, K. N.. (1970). Intestinal microflora in Asiatic cholera. I. ‘Rice-water’ stool. Journal of Infectious Diseases 121, 32.CrossRefGoogle ScholarPubMed
Gorbach, S. L., Nahas, L., Plaut, A. G., Weinstein, L., Patterson, J. F. & Levitan, R. (1968). Studies on intestinal microflora. V. Fecal microbial ecology in ulcerative colitis and regional enteritis: relationship to severity of disease and chemotherapy. Gastroenterology 54, 575.CrossRefGoogle ScholarPubMed
Gossling, J. & Slack, J. M. (1974). Predominant gram-positive bacteria in human feces: numbers, variety, and persistence. Infection and Immunity 9, 719.CrossRefGoogle ScholarPubMed
Hill, M. J., Crowther, J. S., Drasar, B. S., Hawkesworth, G., Aries, J. & Williams, R. E. O. (1971). Bacteria and aetiology of cancer of large bowel. Lancet 1, 95.CrossRefGoogle ScholarPubMed
Holdeman, L. V., Cato, E. P. & Moore, W. E. C. (1977). Anaerobe Laboratory Manual, 4th ed.Blacksburg: V.P.I. Anaerobe Laboratory, Virginia Polytechnic Institute and State University.Google Scholar
Mallory, A., Savage, D., Kern, F. & Smith, J. G. (1973). Patterns of bile acids and microflora in the human small intestine. II. Microflora. Gastroenterology 64, 34.CrossRefGoogle ScholarPubMed
Mitsuoka, T. & Ohno, K. (1977). Die Faekalflora bei Menschen. V. Mitteilung: Die Schwankungen in der Zusammensetzung der Faekalflora gesunder Erwachsener. Zentralblatt für Bakteriologie und Hygiene I. Abt. Orig. A 238, 228.Google Scholar
Moore, W. E. C., Cato, E. P. & Holdeman, L. V. (1969). Anaerobic bacteria of the gastrointestinal flora and their occurrence in clinical infections. Journal of Infectious Diseases 119, 641.Google ScholarPubMed
Moore, W. E. C., & Holdeman, L. V. (1974). Human fecal flora: the normal flora of 20 Japanese-Hawaiians. Applied Microbiology 27, 961.CrossRefGoogle ScholarPubMed
Siegel, S. (1956). Nonparametric statistics for the Behavorial Sciences. New York: McGraw-Hill Book Company Inc.Google Scholar
Speck, R. S., Calloway, D. H. & Hadley, W. K. (1970). Human fecal flora under controlled diet intake. American Journal of Clinical Nutrition 23, 1488.CrossRefGoogle ScholarPubMed
Vince, A., Dyer, N. H., O'Grady, F. W. & Dawson, A. M. (1972). Bacteriological studies in Crohn's disease. Journal of Medical Microbiology 5, 219.CrossRefGoogle ScholarPubMed
Wensinck, F. (1975). The faecal flora of patients with Crohn's disease. Antonie van Leeuwenhoek 41, 214.CrossRefGoogle ScholarPubMed
Wensinck, F. (1976). Faecal flora of Crohn's patients. Serological differentiation between Crohn's disease and ulcerative colitis. In The Management of Crohn's Disease (ed. Weterman, I. T., Peña, A. S. and Booth, C. C.), Amsterdam–Oxford: Excerpta Medica.Google Scholar
Wensinck, F. & Ruseler-van Embden, J. G. H. (1971). The intestinal flora of colonization-resistant mice. Journal of Hygiene 69, 413.CrossRefGoogle ScholarPubMed
Wensinck, F. & van de Merwe, J. P. (1981). Serum agglutinins to Eubacterium and Peptostreptococcus species in Crohn's and other diseases. Journal of Hygiene 87, 13.Google ScholarPubMed
West, B., Lendrum, R., Hill, M. J. & Walker, G. (1974). Effects of sulphasalazine (Salazopyrin) on faecal flora in patients with inflammatory bowel disease. Gut 15, 960.CrossRefGoogle ScholarPubMed