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High levels of Schistosoma mansoni infections among schoolchildren in central Sudan one year after treatment with praziquantel

Published online by Cambridge University Press:  08 June 2011

A.M. Ahmed
Affiliation:
Schistosomiasis Research Laboratory, Faculty of Science, University of Khartoum, Sudan
L.A. El Tash
Affiliation:
Health Economic Center Faculty of Economics, University of Khartoum, Sudan
E.Y. Mohamed
Affiliation:
Faculty of Medicine, University of Khartoum, Sudan
I. Adam*
Affiliation:
Faculty of Medicine, University of Khartoum, Sudan
*
*Fax: +249183771211 E-mail: ishagadam@hotmail.com

Abstract

A longitudinal study was conducted to evaluate the impact of praziquantel (PZQ) for the treatment of Schistosoma mansoni infection among schoolchildren in Al Gunaid in Central Sudan. A cohort of schoolchildren (6–15 years of age) was investigated before and 1 year after treatment with a single dose of PZQ 40 mg/kg. Parasitological examinations for S. mansoni were performed before and after treatment, and prevalence and intensity of infection were analysed. Of 2741 schoolchildren recruited from six elementary schools at baseline, 2521 were successfully traced and re-examined at follow-up, with two complete sets of longitudinal parasitological data on S. mansoni. Boys showed significantly higher prevalence of S. mansoni infection than girls. A single dose of PZQ reduced the overall prevalence of S. mansoni infection by 36.7% (from 59.1 to 37.4%) and the intensity of infection by 41.1% (from 116.7 to 68.7 eggs per gram of stool) 1 year after treatment. The reduction in prevalence was significantly higher among the group of children with heavy infections (by 76.1%, from 6.7 to 1.6%) and among girls (by 54.1%, 42.3 to 19.4%) at 1 year after treatment. Thus, in spite of a significant reduction in the prevalence and intensity of S. mansoni infection 1 year after PZQ treatment, the prevalence of the disease was still high and further research is needed on this topic.

Type
Research Papers
Copyright
Copyright © Cambridge University Press 2011

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References

Ahmed, E.S., Daffalla, A., Christensen, N.O. & Madsen, H. (1996) Patterns of infection and transmission of human schistosomiasis mansoni and schistosomiasis haematobium in White Nile Province, Sudan. Annals of Tropical Medicine and Parasitology 90, 173180.Google Scholar
Ahmed, A.A., Afifi, A.A. & Adam, I. (2010) High prevalence of Schistosoma haematobium infection in Gereida Camp, in southern Darfur, Sudan. Annals of Tropical Medicine and Parasitology 103, 741743.CrossRefGoogle Scholar
Chitsulo, L., Engels, D., Montresor, A. & Savioli, L. (2000) The global status of schistosomiasis and its control. Acta Tropica 77, 4151.CrossRefGoogle ScholarPubMed
Davis, A. (2004) Clinical trials in parasitic diseases. Transactions of the Royal Society of Tropical Medicine and Hygiene 98, 139141.CrossRefGoogle ScholarPubMed
Gryseels, B., Mbaye, A., de Vlas, S.J., Stelma, F.F., Guisse, F., Van Lieshout, L., Faye, D., Diop, M., Ly, A., Tchuem-Tchuente, L.A., Engels, D. & Polman, K. (2001) Are poor responses to praziquantel for the treatment of Schistosoma mansoni infections in Senegal due to resistance? An overview of the evidence. Tropical Medicine and International Health 6, 864873.Google Scholar
Ismail, M., Metwally, A., Farghaly, A., Bruce, J., Tao, L.F. & Bennett, J.L. (1996) Characterization of isolates of Schistosoma mansoni from Egyptian villagers that tolerate high doses of praziquantel. American Journal of Tropical Medicine and Hygiene 55, 214218.CrossRefGoogle ScholarPubMed
Jordan, P. & Webbe, G. (1993) Epidemiology. pp. 87158in Jordan, P., Webbe, G. & Sturrock, R.F. (Eds) Human schistosomiasis. Wallingford, UK, CAB International.Google Scholar
Kabatereine, N.B., Brooker, S., Koukounari, A., Kazibwe, F., Tukahebwa, E.M., Fleming, F.M., Zhang, Y., Webster, J.P., Stothard, J.R. & Fenwick, A. (2007) Impact of a national helminth control programme on infection and morbidity in Ugandan schoolchildren. Bulletin of the World Health Organization 85, 9199.Google Scholar
Lamberton, P.H., Hogan, S.C., Kabatereine, N.B., Fenwick, A. & Webster, J.P. (2010) In vitro praziquantel test capable of detecting reduced in vivo efficacy in Schistosoma mansoni human infections. American Journal of Tropical Medicine and Hygiene 83, 13401347.Google Scholar
Mahgoub, H.M., Mohamed, A.A., Magzoub, M., Gasim, G.I., Eldein, W.N., Ahmed, A.A. & Adam, I. (2010) Schistosoma mansoni infection as a predictor of severe anemia in schoolchildren in eastern Sudan. Journal of Helminthology 84, 132135.Google Scholar
Mohamed, A.A., Mahgoub, H.M., Magzoub, M., Gasim, G.I., Eldein, W.N., Ahmed, A.A. & Adam, I. (2009) Artesunate plus sulfadoxine/pyrimethamine versus praziquantel in the treatment of Schistosoma mansoni in eastern Sudan. Transactions of the Royal Society of Tropical Medicine and Hygiene 103, 10621064.Google Scholar
Montresor, A., Crompton, D.W., Bundy, D.A.P., Hall, A. & Savioli, L. (1998) Guidelines for the evaluation of soil-transmitted helminthiasis and schistosomiasis at community level. Geneva, World Health Organization.Google Scholar
Steinmann, P., Keiser, J., Bos, R., Tanner, M. & Utzinger, J. (2006) Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk. Lancet Infectious Disease 6, 411425.Google Scholar
Stelma, F.F., Talla, I., Sow, S., Kongs, A., Niang, M., Polman, K., Deelder, A.M. & Gryseels, B. (1995) Efficacy and side effects of praziquantel in an epidemic focus of Schistosoma mansoni. American Journal of Tropical Medicine and Hygiene 53, 167170.Google Scholar
Teesdale, C.H. & Amin, M.A. (1976) A simple thick smear technique for diagnosis of S. mansoni. Bulletin of the World Health Organization 54, 703705.Google Scholar
Touré, S., Zhang, Y., Bosqué-Oliva, E., Ky, C., Ouedraogo, A., Koukounari, A., Gabrielli, A.F., Bertrand, S., Webster, J.P. & Fenwick, A. (2008) Two-year impact of single praziquantel treatment on infection in the national control programme on schistosomiasis in Burkina Faso. Bulletin of the World Health Organization 86, 780787.Google Scholar
Utzinger, J., N'Goran, E.K., N'Dri, A., Lengeler, C. & Tanner, M. (2000) Efficacy of praziquantel against Schistosoma mansoni with particular consideration for intensity of infection. Tropical Medicine and International Health 5, 771778.Google Scholar
Van der Werf, M.J., de Vlas, S.J., Brooker, S., Looman, C.W., Nagelkerke, N.J., Habbema, J.D. & Engels, D. (2003) Quantification of clinical morbidity associated with schistosome infection in sub-Saharan Africa. Acta Tropica 86, 125139.CrossRefGoogle ScholarPubMed
WHO (1993) The control of schistosomiasis. Second report of the WHO expert committee, Technical Report Series 86. Geneva, World Health Organization.Google Scholar
WHO (1999) Report of the WHO informal consultation on schistosomiasis control. Geneva, World Health Organization.Google Scholar
WHO (2002) Prevention and control of schistosomiasis and soil-transmitted helminthiasis. Report of a WHO expert committee. Technical Report Series No. 912, pp. 1–57. Geneva, World Health Organization.Google Scholar
WHO (2006) Preventive chemotherapy in human helminthiasis. Geneva, World Health Organization.Google Scholar
Zhang, Y., Koukounari, A., Kabatereine, N., Fleming, F., Kazibwe, F., Tukahebwa, E., Stothard, J.R., Webster, J.P. & Fenwick, A. (2007) Parasitological impact of two-year preventive chemotherapy on schistosomiasis and soil-transmitted helminthiasis in Uganda. BMC Medicine 5, 2.CrossRefGoogle Scholar