Hostname: page-component-848d4c4894-pftt2 Total loading time: 0 Render date: 2024-05-15T08:50:47.862Z Has data issue: false hasContentIssue false
  • English
  • Français

Glutathione concentrations in the red cells of Merino sheep

Published online by Cambridge University Press:  27 March 2009

M. De La Haba ,
A Moreno ,
D. Llanes  and
E. M. Tucker
M. De La Haba
Affiliation:
Departamento de Genética Instituto de Zootecnia, Universidad de Córdoba, 14005 Córdoba, Spain
A Moreno
Affiliation:
Departamento de Genética Instituto de Zootecnia, Universidad de Córdoba, 14005 Córdoba, Spain
D. Llanes
Affiliation:
Departamento de Genética Instituto de Zootecnia, Universidad de Córdoba, 14005 Córdoba, Spain
E. M. Tucker
Affiliation:
AFRC, Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, CB2 4AT
Get access Rights & Permissions [Opens in a new window]

Extract

Tasmanian Merino sheep show a bimodal distribution in the concentration of reduced glutathione (GSH) in their red cells, 40% of sheep having GSH values of around 27 mg GSH/100 ml red cells and 60% with values of about 92 mg GSH/100 ml red cells (Tucker & Kilgour, 1972). The GSH deficiency was shown to be due to an impaired activity of γ-glutamyl cysteine synthetase (γ-GC-S), the enzyme catalysing the first step of GSH biosynthesis (Tucker, Kilgour & Young, 1976). Family data indicated that the deficiency in this strain of Merinos was under the control of a dominant gene, designated GSHL (Tucker et al. 1976). In contrast, Board, Roberts & Evans (1974) reported that a similar type of GSH deficiency in Australian Merino sheep was under the control of a recessive gene. The reasons for this apparent discrepancy remain unresolved.

Type
Short Notes
Information
The Journal of Agricultural Science , Volume 110 , Issue 2 , April 1988 , pp. 401 - 403
Copyright
Copyright © Cambridge University Press 1988

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Beutler, E., Duron, O. & Kelly, B. M. (1963). Improved method for the determination of blood glutathione. Journal of Laboratory and Clinical Medicine 61, 882–888.Google ScholarPubMed
Board, P. G. & Agar, N. S. (1983). Glutathione metabolism in erythrocytes. In Red Blood Cells of Domestic Animals (ed. Agar, N. S. and Board, P. G.), pp. 253–270. B.V. Amsterdam, New York, Oxford: Elsevier Science.Google Scholar
Board, P. G., Roberts, J. & Evans, J. V. (1974). The genetic control of erythrocyte reduced glutathione in Australian Merino sheep. Journal of Agricultural Science, Cambridge 82, 395–398.CrossRefGoogle Scholar
Ellory, J. C., Tucker, E. M. & Deverson, E. V. (1972). The identification of ornithine and lysine at high concentrations in the red cells of sheep. Biochimica el Biophysica Acta 279, 481–483.Google Scholar
Tucker, E. M. & Kilgour, L. (1972). A glutathione deficiency in the red cells of certain Merino sheep. Journal of Agricultural Science, Cambridge 72, 515–516.CrossRefGoogle Scholar
Tucker, E. M., Kilgour, L. & Young, J. D. (1976). The genetic control of red cell glutathione deficiencies in Finnish Landrace and Tasmanian Merino sheep and in crosses between these breeds. Journal of Agricultural Science, Cambridge 87, 315–323.CrossRefGoogle Scholar
Young, J. D., Ellory, J. C. & Tucker, E. M. (1976). Amino acid transport in normal and glutathione deficient sheep erythrocytes. Biochemical Journal 154, 43–48.CrossRefGoogle ScholarPubMed