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A statistical test for the difference in the amounts of DNA variation between two populations

Published online by Cambridge University Press:  17 September 2002

HIDEKI INNAN  and
FUMIO TAJIMA
HIDEKI INNAN
Affiliation:
Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Hongo 7-3-1, Tokyo 113-0033, Japan Present address: Department of Biological Science, University of Southern California, Los Angeles, CA 90089-1340, USA.
FUMIO TAJIMA
Affiliation:
Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Hongo 7-3-1, Tokyo 113-0033, Japan
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Abstract

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A statistical test for the difference in the amounts of DNA variation between two populations is developed. The test statistic involves the covariance of the amount of variation between two populations, which is given by a function of their divergence time, T0. Accordingly, the power (rejection probability) of the test depends on T0. In this article, T0 is treated as unknown because it is very difficult to estimate. The test is most conservative when T0 = ∞ is assumed because the covariance is zero. If T0 = 0 is assumed, the largest value of the rejection probability is obtained. Thus, the test provides a range of rejection probability unless we have a reliable estimate of T0. The test is applied to the PgiC region in three mustard species: Leavenworthia stylosa, L. crassa and L. uniflora. The results of our test show that the level of variation in L. stylosa is significantly higher than those in the other species.

Type
Research Article
Information
Genetics Research , Volume 80 , Issue 1 , August 2002 , pp. 15 - 25
Copyright
© 2002 Cambridge University Press