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On X inactivation in XO embryos of mammals

Published online by Cambridge University Press:  14 April 2009

H. Sharat Chandra
H. Sharat Chandra
Affiliation:
Institute for Genetic Studies, Bangalore, India
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Summary

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By analogy with the situation in coccids it is suggested that in mammalian XO embryos the single X turns heterochromatic in some cells, but that such a change does not result in cell death because the X then reverts back to an euchromatic and active state. This testable alternative to the Gartler–Sparkes hypothesis would imply that the anomalies of the XO Turner syndrome are largely due to imbalance of sex-linked genes rather than developmental damage resulting from cell death and that mammalian X inactivation might become reversed in response to special developmental needs.

Type
Short Papers
Information
Genetics Research , Volume 16 , Issue 2 , October 1970 , pp. 233 - 234
Copyright
Copyright © Cambridge University Press 1970

References

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