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Fasting plasma triacylglycerol concentrations predict adverse changes in lipoprotein metabolism after a normal meal

Published online by Cambridge University Press:  09 March 2007

Jennifer L. Potts
Affiliation:
Oxford Lipid Metabolism Group, Sheikh Rashid Laboratory, Radclifle Infirmary, Oxford OX2 6HE
Sandy M. Humphreys
Affiliation:
Oxford Lipid Metabolism Group, Sheikh Rashid Laboratory, Radclifle Infirmary, Oxford OX2 6HE
Simon W. Coppack
Affiliation:
Oxford Lipid Metabolism Group, Sheikh Rashid Laboratory, Radclifle Infirmary, Oxford OX2 6HE
Rachel M. Fisher
Affiliation:
Oxford Lipid Metabolism Group, Sheikh Rashid Laboratory, Radclifle Infirmary, Oxford OX2 6HE
Geoffrey F. Gibbons
Affiliation:
Metabolic Research Laboratory, Nuffield Department of Clinical Medicine, Radclifle Infirmary, Oxford OX2 6HE
Keith N. Fray
Affiliation:
Oxford Lipid Metabolism Group, Sheikh Rashid Laboratory, Radclifle Infirmary, Oxford OX2 6HE
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Abstract

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The changes in lipoprotein metabolism which follow the ingestion of a large fat load have been well described. The hypothesis was tested that similar changes in lipoprotein metabolism would occur after a relatively normal meal. Plasma and lipoprotein triacylglycerol, cholesterol and apolipoprotein concentrations were determined in twenty subjects (ten female) given a mixed meal containing approximately one-third of the daily intake of major nutrients in the typical Western diet. Fasting plasma triacylglycerol concentrations (range 0.38–2.70 mm/l) and the postprandial rise in plasma triacylglycerol varied considerably between subjects and were significantly associated (P < 0.01). The rise in plasma triacylglycerol corresponded to marked increases in the triacylglycerol concentration of the triacylglycerol-rich lipoproteins (TRL; chylomicrons and very-low-density lipoproteins). TRL cholesterol also increased after the meal. An increase in high-density-lipoprotein (HDL)-triacylglycerol following the meal was accompanied by a decrease in HDL-cholesterol concentration, presumably due to the action of the cholesteryl-ester transfer protein. The increases in HDL-triacylglycerol and in TRL- cholesterol were correlated with the postprandial rise in triacylglycerol in the TRL (P < 0.01). We conclude that potentially adverse changes occur in both triacylglycerol-rich and high-density lipoproteins following a typical mixed meal, as they do after large fat loads. The changes are exaggerated in those subjects with greater fasting plasma triacylglycerol concentrations.

Type
Effects of meals on plasma lipids
Copyright
Copyright © The Nutrition Society 1994

References

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