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Vitamin E kinetics in sheep

Published online by Cambridge University Press:  09 March 2007

M. Hidiroglou
Affiliation:
Animal Research Centre, Agriculture Canada, Ottawa, Ontario K1A 0C6, Canada
K. Karpinski
Affiliation:
Food Directorate, Health and Welfare Canada, Tower B, Place Vanier, Vanier, Ontario K1A 1B8, Canada
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Abstract

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1. Kinetics of physiological doses of D-α-[5-Me-3H]tocopherol(200 μCi) administered to twenty-four sheep were studied using one of four routes: intravenous, oral (capsules), intraruminal and intramuscular.

2. Blood samples were withdrawn from the jugular vein periodically for 96 h after the intravenous and oral administrations, for 168 h after the intraruminal administration and for 216 h after the intramuscular administration.

3. The study indicated that the biological availability of α-tocopherol followed the order intravenous > intramuscular > oral > intraruminal.

4. The rate of elimination was in the order intravenous > oral > intraruminal ˜ intramuscular.

5. The intravenous route was fitted with a three-compartment model, whereas the other routes exhibited a good fit for either a one- or two-compartment model.

Type
General Nutrition papers
Copyright
Copyright © The Nutrition Society 1987

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